Following inspections earlier in the year, National Highways has identified a series of maintenance issues on this section of the M3.
While the company says works are progressing well, weekend closures are necessary to allow contractors to complete the work.
This includes installation of an upgraded barrier, resurfacing, road markings and removal of traffic management measures.
From Friday to Monday, the M3 London bound carriageway will be fully closed between 9pm and 6am between junctions 4a (Farnborough/Fleet) and 3 (Bracknell/Woking).
The London bound slip road, approaching from Frimley, will also be closed at junction 4 over the same weekend.
Road users should allow extra time to complete their journeys and follow the official diversion route, which will be fully sign-posted.