The motorway will shut completely between Junction 9 for Leatherhead and 10 for Wisley.
It’s so upgrade works at the Wisley Interchange can continue.
This closure involves a different stretch from the closure which took place last month.
This time, a 19-mile diversion route will be in place which uses the A3 and the A243.
The M25 will be shut from 9pm on Friday, May the 10th to 6am on Monday, May the 13th.
Drivers are being asked not to use their SatNavs and if they stay in the diversion route they will not be charged for the ULEZ.
There will be three more weekend closures this year between July and the end of the year.
This closure is for the installation of a new bridge consisting of 68 beams, each weighing 16 tonnes, and another 4 beams weighing 40 tonnes.
Jonathan Wade, National Highways Senior Project Manager, said:
“This is far from a repeat of the previous closure, as the alternative routes are longer and will be different for over height vehicles and all other traffic.
“Drivers listened to our advice last time which reduced motorway traffic levels by over two thirds and meant delays were limited.
“Our advice again is please only travel if absolutely necessary and make sure you give yourself extra time if you do choose to use the M25.”
