It’s the next part of the ongoing £317 million works to upgrade Junction 10 Wisley Interchange.
The stretch is due to be closed until Monday at 6am.
British Airways has urged passengers travelling to Gatwick or Heathrow to allow extra journey time.
The A3 between junction 10 and Send will also be affected.
Drivers will next face closures on the same stretch of motorway from on the weekend of March the 21st.
The infrastructure project began in 2022 but “extreme weather” has pushed back the expected completion date to spring 2026.
Stay tuned to Jackie for the latest traffic news across the weekend.
