Police were called at around 1.15am to reports of a stabbing in Grove Road.
Officers responded and found a 24-year-old man with stab wounds and he died at the scene a short time later.
His family have been informed and are being supported by specially trained officers.
Chief Superintendent Sean Wilson, responsible for policing in west London, said: “It is tragic that another young man has lost his life in a stabbing. My thoughts are with his family and friends.
“Officers in Hounslow are supporting the murder investigation and I would encourage anyone who knows anything about the circumstances of this incident to contact us immediately.”
A post mortem examination will be carried out in the coming days.
There have been no arrests at this time and enquiries continue.
Any witnesses or anyone with any information is asked to call 101 quoting CAD 274/16Jan. Information can also be shared online.
To remain anonymous contact the independent charity Crimestoppers on 0800 555 111.