Their 2-nil loss to Crystal Palace was their fifth in six top flight games at Old Trafford.
Tottenham beat Brentford by the same score to earn a much-needed win.
In the WSL Chelsea moved 10 points clear at the top of the table following a 1-nil win at Aston Villa.
Arsenal beat Manchester City 4-3.
Everton got past Leicester 4-1 and Liverpool registered a 1-nil win over West Ham.
Crystal Palace drew 1-all at Brighton.
In the National League South Wimbledon lost 3-nil at Hashtag.