Six fire engines and around 40 firefighters have tackled a fire on Milton Way in West Drayton.
Most of the ground floor and a small part of the first floor of a terraced house were alight.
A vehicle at the rear of the property was also alight along with a small part of the ground floor of a neighbouring house.
Control Officers took the first of 18 calls regarding the fire at 2.50pm and the fire was under control by 4pm.
Crews from Hayes, Heathrow, Southall and surrounding fire stations attended the scene.