The changes are being introduced at the junction of Mitcham Lane and Southcroft Road.
Wandsworth Council says it has seen at least five collisions in recent years.
The main changes will see the replacement of the existing mini-roundabout with traffic signals.
There will be new push button pedestrian crossings on each arm of the junction plus advance stop lines.
It will mean some modest changes to parking bays at the junction with new replacement short-term parking and loading bays provided.
