Harlequin’s Marcus Smith and Ollie Lawrence will join the 36-man England squad named by coach George Borthwick.
It’s not known yet whether Smith who plays fly-half for Quins at the Stoop in Twickenham will be fully fit to play in the Calcutta Cup.
George Martin and Luke Cowan-Dickie also return from injury as Steve Borthwick’s side aim for three consecutive wins.