45 year old David Ackerley, was reported missing at around 9.30am on Sunday, the 8th of October.
A short time later officers attended his address in Cedar Court, Boston Manor Road, where he was found dead.
His next of kin were informed and are being supported by specially trained officers.
A special post-mortem examination determined brain swelling and a bleed on the brain as the primary cause of death.
Detectives from Specialist Crime are investigating.
A man, aged 33 and a woman, aged 35 have been arrested in the Uxbridge area on suspicion of murder and theft.
They are in police custody.
Detective Chief Inspector Geoff Grogan said: “David’s grieving family have many questions about what happened to him, and we are now trying to provide them with answers.
“Part of this important work is building a picture of David’s life, the people he associated with and incidents he was involved in.
“We know David was assaulted outside his address in Boston Manor Road around 20:30hrs on Saturday, 30 September, during which he sustained an injury to his face that required hospital treatment. This was under investigation.
“I’m sure many people will know and recognise David from the local area. He had his vulnerabilities and people will have seen him out and about.
“Two people arrested are now in police custody, but we still need the public’s help to know more about David, or about any incidents he might have been involved in. Please contact us without delay.”
Anyone with information or material like pictures and video that could help police can submit it directly to officers via this web link – https://mipp.police.uk/operation/01MPS23V82-PO1 – or using the QR code below.
Alternatively call 101 or post @MetCC ref 0524683/23., or to remain 100% anonymous contact the independent charity Crimestoppers on 0800 555 111.