Its round five of Gallagher PREM and Harlequins welcome Newcastle Red Bulls to the Twickenham Stoop.
The Quarters have only won one of their opening four games and today they host a team propping up the table with no wins this season.
Fullback Tyrone Green is due to earn his 100th cap for Harlequins and Zach Carr earns his first start at no.8 in the premiership campaign.
Kick-off is 15:00hrs.