The defending champion looks to progress to the semi-finals this afternoon when he faces Andrey Rublev on Centre Court.
Top seed Carlos Alcaraz underlined his status as the player most likely to challenge Djokovic.
He got a 3-sets-to-1 victory over 2021 finalist Matteo Berrettini to reach the last eight at the All England Club for the first time.
Elsewhere, eighth seed Jannik Sinner goes up against Roman Safiullin in the quarter-finals later.
In the women’s draw, world number one Iga Swiatek gets play under way on Centre Court against Elina Svitolina , while American Jessica Pegula faces Marketa Vondrousova.
